Sox9 Increases the Proliferation and Colony-forming Activity of Outer Root Sheath Cells CulturedIn Vitro
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چکیده
منابع مشابه
Sox9 Increases the Proliferation and Colony-forming Activity of Outer Root Sheath Cells Cultured In Vitro.
BACKGROUND β-catenin plays a pivotal role in hair follicle development and hair growth cycle. OBJECTIVE The aim of this study was to identify β-catenin-regulated genes in cultured human hair outer root sheath (ORS) cells. METHODS Primary cultured ORS cells were transduced with recombinant adenovirus expressing N-terminal truncated β-catenin (constitutive active form), and β-catenin-regulate...
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A specialized quiescent population of hair follicle stem cells, residing in the hair follicle outer root sheath cells (ORSCs), has previously demonstrated pluripotency for differentiation into neural stem cells (NSCs). A previous study indicated that nestin‑positive hair follicle ORSCs are able to differentiate into neurons. However, little has been reported on the isolation of nestin‑negative ...
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متن کاملSox9 Is Essential for Outer Root Sheath Differentiation and the Formation of the Hair Stem Cell Compartment
BACKGROUND The mammalian hair represents an unparalleled model system to understand both developmental processes and stem cell biology. The hair follicle consists of several concentric epithelial sheaths with the outer root sheath (ORS) forming the outermost layer. Functionally, the ORS has been implicated in the migration of hair stem cells from the stem cell niche toward the hair bulb. Howeve...
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ژورنال
عنوان ژورنال: Annals of Dermatology
سال: 2011
ISSN: 1013-9087
DOI: 10.5021/ad.2011.23.2.138